基因名:
BAAT
产品别名:
BACAT; BACD1; BAT; HCHO; BAAT; bile acid-CoA:amino acid N-acyltransferase; bile acid-CoA:amino acid N-acyltransferase; bile acid-CoA:amino acid N-acyltransferase; bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase); bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase); bile acid-CoA thioesterase; choloyl-CoA hydrolase; long-chain fatty-acyl-CoA hydrolase; 长链脂肪酸酰基辅酶A水解酶;
背景信息:
BAAT (bile acid Coenzyme A: amino acid N-acyltransferase) is involved in bile acid metabolism. In liver hepatocytes BAAT catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to glycine and taurine, before excretion into bile canaliculi. This is the second step in the formation of bile acid-amino acid conjugates. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. BAAT may also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids.