基因名：
ARNT
产品别名：
HIF-1-beta； HIF-1beta； HIF1-beta； HIF1B； HIF1BETA； TANGO； bHLHe2； ARNT； aryl hydrocarbon receptor nuclear translocator； aryl hydrocarbon receptor nuclear translocator； aryl hydrocarbon receptor nuclear translocator； class E basic helix-loop-helix protein 2； dioxin receptor, nuclear translocator； hypoxia inducible factor 1 subunit beta； hypoxia-inducible factor 1, beta subunit； 缺氧诱导因子1β/HIF-1β； 芳香烃受体核转位因子(ARNT)；
背景信息：
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
