基因名：
FAS
产品别名：
ALPS1A； APO-1； APT1； CD95； FAS1； FASTM； TNFRSF6； FAS； Fas cell surface death receptor； Fas cell surface death receptor； tumor necrosis factor receptor superfamily member 6； APO-1 cell surface antigen； CD95 antigen； FASLG receptor； Fas (TNF receptor superfamily, member 6)； Fas AMA； TNF receptor superfamily member 6； apoptosis antigen 1； apoptosis signaling receptor FAS； apoptosis-mediating surface antigen FAS； mutant tumor necrosis receptor superfamily member 6； tumor necrosis factor receptor superfamily, member 6； 凋亡相关因子(FAS)； 凋亡相关因子(FAS)真核蛋白； 磷酸化载脂蛋白A1； 载脂蛋白1；
背景信息：
FAS(TNFRSF6) is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
