基因名：
APBB1
产品别名：
FE65； MGC:9072； RIR； APBB1； amyloid beta precursor protein binding family B member 1； amyloid beta precursor protein binding family B member 1； amyloid beta precursor protein binding family B member 1； adaptor protein FE65a2； amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)； stat-like protein； 淀粉样蛋白β前体蛋白结合蛋白B1(APBB1)； 磷酸化铁蛋白Fe65； 铁蛋白Fe65；
背景信息：
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
