基因名：
APBA2
产品别名：
D15S1518E； HsT16821； LIN-10； MGC:14091； MINT2； X11-BETA； X11L； APBA2； amyloid beta precursor protein binding family A member 2； amyloid beta precursor protein binding family A member 2； amyloid-beta A4 precursor protein-binding family A member 2； X11-like protein； adapter protein X11beta； amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)； mint-2； neuron-specific X11L protein； neuronal munc18-1-interacting protein 2； phosphotyrosine-binding/-interacting domain (PTB)-bearing protein； β淀粉样前体蛋白结合蛋白2； 淀粉样蛋白β前体蛋白结合蛋白A2(APBA2)；
背景信息：
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3).
