基因名:
AKT2
产品别名:
HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA; AKT2; AKT serine/threonine kinase 2; AKT serine/threonine kinase 2; RAC-beta serine/threonine-protein kinase; PKB beta; RAC-PK-beta; murine thymoma viral (v-akt) homolog-2; protein kinase Akt-2; protein kinase B beta; putative v-akt murine thymoma viral oncoprotein 2; rac protein kinase beta; v-akt murine thymoma viral oncogene homolog 2; 磷酸化蛋白激酶B2; 蛋白激酶B2; 蛋白激酶Bβ(PKBb);
背景信息:
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008].