基因名：
AP2A1
产品别名：
ADTAA； AP2-ALPHA； CLAPA1； AP2A1； adaptor related protein complex 2 subunit alpha 1； adaptor related protein complex 2 subunit alpha 1； AP-2 complex subunit alpha-1； 100 kDa coated vesicle protein A； adapter-related protein complex 2 alpha-1 subunit； adapter-related protein complex 2 subunit alpha-1； adaptin, alpha A； adaptor protein complex AP-2 subunit alpha-1； adaptor related protein complex 2 alpha 1 subunit； alpha-adaptin A； alpha1-adaptin； clathrin assembly protein complex 2 alpha-A large chain； clathrin-associated/assembly/adaptor protein, large, alpha 1； plasma membrane adaptor HA2/AP2 adaptin alpha A subunit； 衔接因子相关蛋白复合体2α1(AP2a1)； 衔接蛋白α-Adaptin；
背景信息：
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate 100 kDa gene products with similar domain structures (alpha and beta adaptin) and a 50 and 17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.
