基因名：
ADH5
产品别名：
ADH-3； ADHX； AMEDS； BMFS7； FALDH； FDH； GSH-FDH； GSNOR； HEL-S-60p； ADH5； alcohol dehydrogenase 5 (class III), chi polypeptide； alcohol dehydrogenase 5 (class III), chi polypeptide； alcohol dehydrogenase class-3； S-(hydroxymethyl)glutathione dehydrogenase； S-nitrosoglutathione reductase； alcohol dehydrogenase (class III), chi polypeptide； alcohol dehydrogenase class chi chain； alcohol dehydrogenase class-III； epididymis secretory sperm binding protein Li 60p； formaldehyde dehydrogenase； glutathione-dependent formaldehyde dehydrogenase； 乙醇脱氢酶5；
背景信息：
The alcohol dehydrogenase family of proteins metabolize a wide variety of substrates, including retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. ADH5 (alcohol dehydrogenase 5 (class III)), also known as FDH (formaldehyde dehydrogenase), ADHX, ADH-3 or GSNOR, is a 374 amino acid cytoplasmic protein that belongs to the class III subfamily of alcohol dehydrogenases. Expressed ubiquitously, ADH5 uses iron as a cofactor to catalytically oxidize both long-chain primary alcohols and S-hydroxymethyl-glutathione, a product formed spontaneously between formaldehyde and glutathione. ADH5 exists as a homodimer and, via its ability to oxidize S-hydroxymethyl-glutathione and, thus, eliminate formaldehyde, functions as an important component of cellular metabolism. Genetic variations in the gene encoding ADH5 may affect drug and alcohol dependence in humans.
