基因名：
ACO1
产品别名：
ACONS； HEL60； IREB1； IREBP； IREBP1； IRP1； ACO1； aconitase 1； aconitase 1； cytoplasmic aconitate hydratase； aconitase 1, soluble； aconitate hydratase, cytoplasmic； citrate hydro-lyase； cytoplasmic aconitase； cytosplasmic aconitase； epididymis luminal protein 60； epididymis secretory sperm binding protein； ferritin repressor protein； iron regulatory protein 1； iron-responsive element-binding protein 1； soluble aconitase； 磷酸化铁调节蛋白1； 铁调节蛋白1； 顺乌头酸酶1(ACO1)；
背景信息：
Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.
