基因名：
ABL1
产品别名：
ABL； BCR-ABL； CHDSKM； JTK7； bcr/abl； c-ABL； c-ABL1； p150； v-abl； ABL1； ABL proto-oncogene 1, non-receptor tyrosine kinase； ABL proto-oncogene 1, non-receptor tyrosine kinase； tyrosine-protein kinase ABL1； ABL protooncogene 1 nonreceptor tyrosine kinase； Abelson tyrosine-protein kinase 1； BCR-ABL1 p190； BCR/ABL e8a2 fusion； BCR/ABL1 e1a2 fusion protein； bcr/c-abl oncogene protein； c-abl oncogene 1, receptor tyrosine kinase； proto-oncogene c-Abl； proto-oncogene tyrosine-protein kinase ABL1； v-abl Abelson murine leukemia viral oncogene homolog 1； 磷酸化非受体酪氨酸激酶c-Abl； 非受体酪氨酸激酶c-Abl；
背景信息：
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].
