基因名：
Galntl5
产品别名：
1700021B12Rik； Galnt15； Galntl5； UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5； UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5； inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5； UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15； UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15； galNAc-T15； polypeptide GalNAc transferase 15； polypeptide N-acetylgalactosaminyltransferase-like 5； pp-GaNTase 15； protein-UDP acetylgalactosaminyltransferase 15； putative polypeptide N-acetylgalactosaminyltransferase-like protein 5； GalNAc-TL5蛋白；
背景信息：
GalNAc-TL4 utilizes manganese and calcium as cofactors and is expressed in testis. GalNAc-TL5 may assist with the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on protein receptors and likely catalyzes the initial reaction in O-linked oligosaccharide biosynthesis. Unlike other members of the GalNAc-T subfamily, GalNAc-TL5 does not contain a C-terminal ricin B-type lectin domain. GalNAc-TL5 contains two conserved domains located in its glycosyltransferase region. The N-terminal domain, also known as domain A or GT1 motif, may be involved in manganese coordination and substrate binding while the C-terminal domain, also known as domain B or Gal/GalNAc-T motif, is likely involved in catalytic reactions and UDP-Gal binding. GalNAc-TL5 exists as two alternatively spliced isoforms.
