靶标：
PRIMPOL
产品别名：
CCDC111； MYP22； Primpol1； PRIMPOL； primase and DNA directed polymerase； primase and DNA directed polymerase； DNA-directed primase/polymerase protein； coiled-coil domain-containing protein 111； hPrimpol1；
背景信息：
DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. PRIMPOL shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. It is involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. PRIMPOL is required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. PRIMPOL has non-overlapping function with POLH.
