The HMCN1 gene encodes the Hemicentin-1 protein in human , which is a large extracellular member of the immunoglobulin superfamily. Mutations in this gene may be associated with age-related macular degeneration. HMCN1 may play a role in the architecture of adhesive and flexible epithelial cell junctions.HMCN1 is one of the significant changes in the early stages of glomerular damage. Diseases associated with HMCN1 include Macular Degeneration, Age-Related, 1 and Basal Laminar Drusen.