靶标:
Arhgap10
产品别名:
A930033B01Rik; PS-GAP; PSGAP; PSGAP-m; PSGAP-s; Arhgap10; Rho GTPase activating protein 10; Rho GTPase activating protein 10; rho GTPase-activating protein 10; PH and SH3 domain-containing rhoGAP protein; rho-type GTPase-activating protein 10;
背景信息:
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).