靶标：
Atp6v0e2
产品别名：
0610006O14Rik； NM9.2； Atp6v0e2； ATPase, H+ transporting, lysosomal V0 subunit E2； ATPase, H+ transporting, lysosomal V0 subunit E2； V-type proton ATPase subunit e 2； ATPase, H+ transporting, lysosomal, V0 subunit E； V-ATPase subunit e 2； vacuolar proton pump subunit e 2；
背景信息：
Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]). [supplied by OMIM]
