靶标：
Mvb12b
产品别名：
2610200O14Rik； 2610528K11Rik； AI414895； Fam125b； Mvb12b； multivesicular body subunit 12B； multivesicular body subunit 12B； multivesicular body subunit 12B； ESCRT-I complex subunit MVB12B； family with sequence similarity 125, member B；
背景信息：
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
