靶标：
CDC42BPG
产品别名：
DMPK2； HSMDPKIN； KAPPA-200； MRCKG； MRCKgamma； CDC42BPG； CDC42 binding protein kinase gamma； CDC42 binding protein kinase gamma； serine/threonine-protein kinase MRCK gamma； CDC42 binding protein kinase gamma (DMPK-like)； DMPK-like gamma； MRCK gamma； myotonic dystrophy kinase-related CDC42-binding kinase gamma； myotonic dystrophy protein kinase like protein； myotonic dystrophy protein kinase-like alpha； myotonic dystrophy protein kinase-like gamma；
背景信息：
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation.,function:May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 CNH domain.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subcellular location:Concentrates at the leading edge of cells.,subunit:Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42.,tissue specificity:Expressed in heart and skeletal muscle.,
