靶标：
Ilp2
产品别名：
CG8167； DILP； DILP 2； DILP-2； DILP2； Dilp； Dilp 2； Dilp-2； Dilp2； Dmel\CG8167； ILP2； IRP； Ilp； Ilp-2； dILP-2； dILP2； dIlp2； dilp； dilp-2； dilp2； dipl2； ilp2； Ilp2； Insulin-like peptide 2； Insulin-like peptide 2； Insulin-like peptide 2； CG8167-PA； Dilp2； Ilp2-PA； Insulin- related peptide 2； Insulin-like peptide； Insulin-related peptide； drosophila insulin like peptide 2； drosophila insulin-like peptide 2； drosophila insulin-like receptor； insulin-like 2； insulin-like peptide-2；
背景信息：
Protects against apoptosis mediated by BAX.Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP ILP-1 MIHA, and Livin KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
