靶标：
EEF1AKMT3
产品别名：
FAM119B； METTL21B； EEF1AKMT3； EEF1A lysine methyltransferase 3； EEF1A lysine methyltransferase 3； EEF1A lysine methyltransferase 3； eEF1A-KMT3； family with sequence similarity 119, member B； hepatocellular carcinoma-associated antigen 557a； hepatocellularcarcinoma-associated antigen HCA557a； methyltransferase like 21B； methyltransferase-like protein 21B； protein-lysine methyltransferase METTL21B； 甲基化样蛋白21B；
背景信息：
METTL21B (also known as EEF1AKMT3, FAM119B) is a member of the Family 16 group of methyltransferases. Despite its close relation to the other METTL21 proteins (METTL21A, C and D), METTL21B has a different substrate to both METTL21A (HSPA-KMT) and METTL21D (VCP-KMT). The main difference between these proteins is their N-terminal regions, beyond the core catalytic seven-beta-strand fold, which may therefore be responsible determining their substrate specificities. METTL21B is expressed at medium to high levels in every tissue type, and has been reported to localize to the nucleus, the cytoplasm and centrosomes. METTL21B has been implicated in multiple sclerosis because of changes in its expression in a susceptibility genotype.
