靶标:
SLC30A8
产品别名:
ZNT8; ZnT-8; SLC30A8; solute carrier family 30 member 8; solute carrier family 30 member 8; zinc transporter 8; solute carrier family 30 (zinc transporter), member 8; zinc transporter ZnT-8; 溶质载体家族30成员8(SLC30A8); 锌转运体8;
背景信息:
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010],