靶标：
UBE2U
产品别名：
UBE2U； ubiquitin conjugating enzyme E2 U； ubiquitin conjugating enzyme E2 U； ubiquitin-conjugating enzyme E2 U； E2 ubiquitin-conjugating enzyme U； testicular tissue protein Li 216； ubiquitin carrier protein U； ubiquitin conjugating enzyme E2 U (putative)； ubiquitin conjugating enzyme E2U (putative)； ubiquitin-protein ligase U； 泛素蛋白连接酶U；
背景信息：
function:E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.,miscellaneous:A cysteine residue is required for ubiquitin-thioester formation.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 1 IQ domain.,subunit:Interacts with 26S proteasomes. Binds CAND2.,tissue specificity:Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.,
