靶标:
OSCAR
产品别名:
PIGR3; PIgR-3; OSCAR; osteoclast associated Ig-like receptor; osteoclast associated Ig-like receptor; osteoclast-associated immunoglobulin-like receptor; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2; osteoclast associated, immunoglobulin-like receptor; poly-Ig receptor 3; polymeric immunoglobulin receptor 3; 破骨细胞关联受体(OSCAR); 破骨细胞相关受体;
背景信息:
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013],