靶标:
EGLN2
产品别名:
EIT-6; EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1; EGLN2; egl-9 family hypoxia inducible factor 2; egl-9 family hypoxia inducible factor 2; prolyl hydroxylase EGLN2; HIF-prolyl hydroxylase 1; egl nine homolog 2; estrogen-induced tag 6; hypoxia-inducible factor prolyl hydroxylase 1; prolyl hydroxylase domain-containing protein 1; 脯氨酰羟化酶;
背景信息:
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.