靶标:
PLCZ1
产品别名:
NYD-SP27; PLC-zeta-1; PLCzeta; SPGF17; PLCZ1; phospholipase C zeta 1; phospholipase C zeta 1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; PI-phospholipase C zeta 1; phosphoinositide phospholipase C-zeta-1; testicular tissue protein Li 145; testis-development related NYD-SP27; 磷酯酶Cζ1(PLCz1); 磷酸肌醇磷脂酶PLCZ1;
背景信息:
The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants.