靶标：
CRACR2A
产品别名：
EFCAB4B； RAB46； CRACR2A； calcium release activated channel regulator 2A； calcium release activated channel regulator 2A； EF-hand calcium-binding domain-containing protein 4B； CRAC channel regulator 2A； CRAC regulator 2A； Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A； EF-hand calcium binding domain 4B； calcium release-activated calcium channel regulator 2A； ras-related protein Rab-46；
背景信息：
[Isoform 1]: Ca(2+-binding protein that plays a key role in store-operated Ca(2+ entry (SOCE in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+ concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+ resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
