靶标：
GPT2
产品别名：
ALT2； GPT 2； MRT49； NEDSPM； GPT2； glutamic--pyruvic transaminase 2； glutamic--pyruvic transaminase 2； alanine aminotransferase 2； glutamate pyruvate transaminase 2； glutamic pyruvate transaminase (alanine aminotransferase) 2； glutamic pyruvate transaminase 2； glutamic--alanine transaminase 2； 谷丙转氨酶2； 谷丙转氨酶2(ALT2)；
背景信息：
This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
