靶标：
RNF34
产品别名：
CARP-1； CARP1； RFI； RIF； RIFF； hRFI； RNF34； ring finger protein 34； ring finger protein 34； E3 ubiquitin-protein ligase RNF34； FYVE-RING finger protein MOMO； RING finger protein RIFF； RING-type E3 ubiquitin transferase RNF34； caspase regulator CARP1； caspases-8 and -10-associated RING finger protein 1； human RING finger homologous to inhibitor of apoptosis protein； ring finger protein 34, E3 ubiquitin protein ligase； 环指蛋白34；
背景信息：
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.
