靶标:
Scara5
产品别名:
4932433F15Rik; 4933425F03Rik; AV278087; Tesr; Scara5; scavenger receptor class A, member 5; scavenger receptor class A, member 5; scavenger receptor class A member 5; scavenger receptor class A, member 5 (putative); testis expressed scavenger receptor; A类清道夫受体5(SCARA5); 清道夫受体A亚型5;
背景信息:
function:Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).,similarity:Belongs to the SCARA5 family.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 SRCR domain.,subunit:Homotrimer.,