靶标:
Dynlrb1
产品别名:
2010012N15Rik; 2010320M17Rik; 9430076K19Rik; AV124457; DNLC2A; Dncl2a; km23-1; Dynlrb1; dynein light chain roadblock-type 1; dynein light chain roadblock-type 1; dynein light chain roadblock-type 1; dynein light chain 2A, cytoplasmic; dynein, cytoplasmic, light chain 2A; dynein, cytoplasmic, light polypeptide 2A; 胞质动力蛋白轻链2A;
背景信息:
This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013],