靶标:
ERAP2
产品别名:
L-RAP; LRAP; ERAP2; endoplasmic reticulum aminopeptidase 2; endoplasmic reticulum aminopeptidase 2; endoplasmic reticulum aminopeptidase 2; leukocyte-derived arginine aminopeptidase; 内质网氨基肽酶2; 内质网氨肽酶2(ERAP2);
背景信息:
This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016],