靶标：
Perp
产品别名：
1110017A08Rik； KCP1； KRTCAP1； PIGPC1； THW； Perp； PERP, TP53 apoptosis effector； PERP, TP53 apoptosis effector； p53 apoptosis effector related to PMP-22； KCP-1； keratinocyte-associated protein 1； p53 apoptosis effector related to Pmp22； p53 apoptosis-associated target； p53凋亡相关作用蛋白PMP22；
背景信息：
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
