靶标：
ABHD4
产品别名：
ABH4； ABHD4； abhydrolase domain containing 4, N-acyl phospholipase B； abhydrolase domain containing 4, N-acyl phospholipase B； (Lyso)-N-acylphosphatidylethanolamine lipase； abhydrolase domain-containing protein 4； alpha/beta hydrolase domain-containing protein 4； alpha/beta-hydrolase 4； lyso-N-acylphosphatidylethanolamine lipase； protein ABHD4； α/β水解酶4；
背景信息：
caution:Thr-291 is present instead of the conserved His which is expected to be an active site residue.,function:Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.,similarity:Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.,
