靶标:
TGIF2
产品别名:
TGIF2; TGFB induced factor homeobox 2; TGFB induced factor homeobox 2; homeobox protein TGIF2; 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription factor 2; TGFB-induced factor 2 (TALE family homeobox); transcription growth factor-beta-induced factor 2; TGF-β诱导转录因子2;
背景信息:
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010],