靶标：
RNF213
产品别名：
ALO17； C17orf27； KIAA1618； MYMY2； MYSTR； NET57； RNF213； ring finger protein 213； ring finger protein 213； E3 ubiquitin-protein ligase RNF213； ALK lymphoma oligomerization partner on chromosome 17； E3 ubiquitin-lipopolysaccharide ligase RNF213； RING-type E3 ubiquitin transferase RNF213； mysterin； KIAA1618蛋白； 环指蛋白213；
背景信息：
This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],
