靶标：
MTUS1
产品别名：
ATBP； ATIP； ATIP3； ICIS； MP44； MTSG1； MTUS1； microtubule associated scaffold protein 1； microtubule associated scaffold protein 1； microtubule-associated tumor suppressor 1； AT2 receptor-binding protein； AT2 receptor-interacting protein； AT2R binding protein； angiotensin-II type 2 receptor-interacting protein； erythroid differentiation-related； microtubule associated tumor suppressor 1； mitochondrial tumor suppressor gene 1； transcription factor MTSG1； 微管相关肿瘤抑制因子1； 肿瘤抑制因子1(MTUS1)；
背景信息：
Mitochondrial tumor suppressor 1 (MTSG1) or Microtubule-Associated Scaffold Protein 1 (MTUS1) is a candidate tumor suppressor protein encoded by the MTUS1 gene in humans. It is mapped to 8p22. This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.
