靶标：
CHRNA10
产品别名：
CHRNA10； cholinergic receptor nicotinic alpha 10 subunit； cholinergic receptor nicotinic alpha 10 subunit； neuronal acetylcholine receptor subunit alpha-10； NACHR alpha-10； acetylcholine receptor, nicotinic, alpha 10 (neuronal)； cholinergic receptor, nicotinic alpha 10； cholinergic receptor, nicotinic, alpha 10 (neuronal)； cholinergic receptor, nicotinic, alpha polypeptide 10； nicotinic acetylcholine receptor subunit alpha-10； 烟碱型乙酰胆碱受体α10/AChRα10； 烟碱型胆碱受体α10(CHRNa10)；
背景信息：
function:Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.,miscellaneous:The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Forms hetero-oligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.,tissue specificity:Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.,
