靶标:
TWSG1
产品别名:
TSG; TWSG1; twisted gastrulation BMP signaling modulator 1; twisted gastrulation BMP signaling modulator 1; twisted gastrulation protein homolog 1; twisted gastrulation homolog 1; 扭转原肠胚形成同源物1(TWSG1); 扭转原肠胚形成同源蛋白1;
背景信息:
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).