靶标：
BCCIP
产品别名：
TOK-1； TOK1； BCCIP； BRCA2 and CDKN1A interacting protein； BRCA2 and CDKN1A interacting protein； BRCA2 and CDKN1A-interacting protein； BCCIPalpha； BCCIPbeta； BRCA2 and Cip1/p21 interacting protein； TOK-1alpha； TOK-1beta； cdk inhibitor p21 binding protein； p21- and CDK-associated protein 1； protein TOK-1； 乳腺癌易感基因2和p21蛋白抑制因子；
背景信息：
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
