靶标:
PARL
产品别名:
PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1; PARL; presenilin associated rhomboid like; presenilin associated rhomboid like; presenilins-associated rhomboid-like protein, mitochondrial; mitochondrial intramembrane-cleaving protease PARL; rhomboid 7 homolog 1; 骨骼肌细胞线粒体膜蛋白PARL;
背景信息:
This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016],