靶标：
PIDD1
产品别名：
LRDD； MRT75； PIDD； PIDD1； p53-induced death domain protein 1； p53-induced death domain protein 1； p53-induced death domain-containing protein 1； leucine-rich repeat and death domain-containing protein； leucine-rich repeats and death domain containing； p53-induced protein with a death domain； 含亮氨酸丰富重复死亡域蛋白(LRDD)； 富含亮氨酸重复死亡结构域蛋白；
背景信息：
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.
