靶标:
UBR7
产品别名:
C14orf130; LICAS; UBR7; ubiquitin protein ligase E3 component n-recognin 7; ubiquitin protein ligase E3 component n-recognin 7; putative E3 ubiquitin-protein ligase UBR7; N-recognin-7; RING-type E3 ubiquitin transferase UBR7; ubiquitin protein ligase E3 component n-recognin 7 (putative); 14号染色体开放阅读框130;
背景信息:
This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome.