靶标：
DCUN1D1
产品别名：
DCNL1； DCUN1L1； RP42； SCCRO； SCRO； Tes3； DCUN1D1； defective in cullin neddylation 1 domain containing 1； defective in cullin neddylation 1 domain containing 1； DCN1-like protein 1； DCN1, defective in cullin neddylation 1, domain containing 1； DCUN1 domain-containing protein 1； RP42 homolog； defective in cullin neddylation protein 1-like protein 1； squamous cell carcinoma-related oncogene； 鳞状细胞癌相关蛋白；
背景信息：
Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8 thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity.
