靶标：
DTL
产品别名：
CDT2； DCAF2； L2DTL； RAMP； DTL； denticleless E3 ubiquitin protein ligase homolog； denticleless E3 ubiquitin protein ligase homolog； denticleless protein homolog； DDB1- and CUL4-associated factor 2； RA-regulated nuclear matrix-associated protein； lethal(2) denticleless protein homolog； retinoic acid-regulated nuclear matrix-associated protein； 维甲酸调节核基质相关蛋白；
背景信息：
developmental stage:Expressed in all fetal tissues examined, included brain, lung, liver, and kidney.,function:Required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. Seems to be necessary to ensure proper cell cycle regulation of DNA replication. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. May play a role in cell proliferation of NT2 embryonal carcinoma cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the WD repeat cdt2 family.,similarity:Contains 7 WD repeats.,subcellular location:Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.,subunit:Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1.,tissue specificity:Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.,
