靶标:
GEMIN4
产品别名:
HC56; HCAP1; HHRF-1; NEDMCR; p97; GEMIN4; gem nuclear organelle associated protein 4; gem nuclear organelle associated protein 4; gem-associated protein 4; HCC-associated protein 1; component of gems 4; gemin-4; 脊髓性肌萎缩症蛋白Gemin4;
背景信息:
The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.