靶标:
ADGRE2
产品别名:
CD312; CD97; EMR2; VBU; ADGRE2; adhesion G protein-coupled receptor E2; adhesion G protein-coupled receptor E2; adhesion G protein-coupled receptor E2; CD97 antigen; EGF-like module-containing mucin-like hormone receptor-like 2; Leukocyte antigen CD97; egf-like module containing, mucin-like, hormone receptor-like 2; 含EGF样模块粘蛋白样激素受体2(EMR2);
背景信息:
This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012],