靶标:
CARD10
产品别名:
BIMP1; CARMA3; IMD89; CARD10; caspase recruitment domain family member 10; caspase recruitment domain family member 10; caspase recruitment domain-containing protein 10; Bcl10 binding protein and activator of NFKB; CARD-containing MAGUK 3 protein; CARD-containing MAGUK protein 3; carma 3; BCL10结合蛋白和激活核转录因子;
背景信息:
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008],