靶标：
CLCF1
产品别名：
BSF-3； BSF3； CISS2； CLC； NNT-1； NNT1； NR6； CLCF1； cardiotrophin like cytokine factor 1； cardiotrophin like cytokine factor 1； cardiotrophin-like cytokine factor 1； B-cell stimulatory factor 3； B-cell-stimulating factor 3； CRLF1 associated cytokine-like factor 1； neurotrophin-1/B-cell stimulating factor-3； novel neurotrophin-1； 心营养素样细胞因子1(CLCF1)； 神经营养因子1/B淋巴细胞刺激因子3；
背景信息：
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encodin
