靶标：
ZDHHC17
产品别名：
DHHC-17； DHHC17； HIP14； HIP3； HSPC294； HYPH； ZDHHC17； zinc finger DHHC-type palmitoyltransferase 17； zinc finger DHHC-type palmitoyltransferase 17； palmitoyltransferase ZDHHC17； DHHC domain-containing cysteine-rich protein 17； acyltransferase ZDHHC17； acyltransferase ZDHHC7； huntingtin interacting protein 14； huntingtin interacting protein 3； huntingtin yeast partner H； huntingtin-interacting protein H； putative MAPK-activating protein PM11； putative NF-kappa-B-activating protein 205； zinc finger DHHC domain-containing protein 17； zinc finger DHHC-type containing 17； NFκB激活蛋白205；
背景信息：
catalytic activity:Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.,domain:The DHHC domain is required for palmitoyltransferase activity.,function:Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May be involved in the NF-kappa-B signaling pathway. Has transforming activity.,miscellaneous:The early and prominent pathology of HD is observed in the medium spiny neurons that project into the globus.,similarity:Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.,similarity:Contains 1 DHHC-type zinc finger.,similarity:Contains 5 ANK repeats.,subunit:Binds HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.,tissue specificity:Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney.,
