靶标：
GGA2
产品别名：
VEAR； GGA2； golgi associated, gamma adaptin ear containing, ARF binding protein 2； golgi associated, gamma adaptin ear containing, ARF binding protein 2； ADP-ribosylation factor-binding protein GGA2； VHS domain and ear domain of gamma-adaptin； VHS domain and ear domain-containing protein； gamma-adaptin-related protein 2； golgi-localized, gamma ear-containing, ARF-binding protein 2； γ-衔接蛋白相关蛋白2；
背景信息：
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.
