靶标：
CARD8
产品别名：
CARDINAL； DACAR； DAKAR； NDPP； NDPP1； TUCAN； CARD8； caspase recruitment domain family member 8； caspase recruitment domain family member 8； caspase recruitment domain-containing protein 8； CARD inhibitor of NF-kappaB-activating ligands； apoptotic protein NDPP1； tumor up-regulated CARD-containing antagonist of CASP9； tumor up-regulated CARD-containing antagonist of caspase nine； 凋亡加强结构域蛋白8；
背景信息：
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
